CEREBYX

Drug Name: CEREBYX

CEREBYX DESCRIPTION:
FOSPHENYTOIN - INJECTION (foss-fen-eh-TOE-in)

COMMON CEREBYX BRAND NAME(S):
Cerebyx

CEREBYX SIDE EFFECTS:
Burning/tingling sensations, groin pain, itching, nausea, dizziness, or drowsiness may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. Tell your doctor immediately if any of these serious side effects occur: mental/mood changes, loss of coordination, rash, eye/vision problems. Tell your doctor immediately if any of these unlikely but serious side effects occur: seizures, difficulty speaking, muscle twitching/tremors, severe headache. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: chest pain, changes in hearing, increased thirst/urination, unusually fast/slow/irregular pulse, unusual fatigue, unusual bruising, severe stomach pain, joint/muscle pain, swollen glands, change in the amount of urine. An allergic reaction to CEREBYX is unlikely, but seek medical attention immediately. Symptoms of an allergic reaction include: itching, rash, swelling, dizziness, yellowing skin/eyes, dark urine, fever, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

HOW TO USE CEREBYX:
CEREBYX: CEREBYX is injected into a vein (IV) or a muscle (IM). CEREBYX will be used until you can take an oral form of the drug. Follow all instructions for correct mixing and dilution with IV fluids. Consult your pharmacist. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not discontinue CEREBYX, or any other seizure medication, without your doctor's approval.

CEREBYX USES:
Fosphenytoin is an anticonvulsant, it is used to treat or prevent seizures.

CEREBYX PRECAUTIONS:
Tell your doctor your medical history, especially: any alcohol use, low blood pressure, blood disorders (e.g., anemia, porphyria); thyroid problems (hypothyroid); diabetes; immune disorders (systemic lupus erythematosus); liver or kidney problems; any allergies (especially to phenytoin, phenobarbital, ethosuximide, or carbamazepine). CEREBYX is not recommended for use if you have the following conditions: heart problems (e.g., sinus bradycardia, second and third degree A-V block). CEREBYX may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages. Caution is advised when using CEREBYX in the elderly because they may be more sensitive to the effects CEREBYX may have on the heart. CEREBYX is not recommended for use during pregnancy. Consult your doctor for more details. It is not known if CEREBYX passes into breast milk. Consult your doctor before breast-feeding.

CEREBYX DRUG INTERACTIONS:
Tell your doctor or pharmacist of all prescription and nonprescription drugs you may use, especially: other seizure drugs (e.g., carbamazepine, valproic acid, phenobarbital); "blood thinners" (e.g., warfarin); corticosteroids (e.g., prednisone); hormone replacement therapy (e.g., estrogens); rifamycin antibiotics (e.g., rifampin, rifabutin); heart drugs (e.g., quinidine, amiodarone, nifedipine, digoxin, dopamine); vitamin supplements (e.g., vitamin D, folic acid); azole antifungal drugs (e.g., ketoconazole, itraconazole); anti-ulcer drugs (e.g., cimetidine, omeprazole, sucralfate); antidepressant drugs (e.g., amitriptyline, trazodone, fluoxetine); NSAIDs (e.g., ibuprofen, phenylbutazone); certain diabetes medications (e.g., diazoxide, tolbutamide); sulfa drugs (e.g., sulfamethoxazole); trimethoprim, chloramphenicol, disulfiram, doxycycline, anti-cancer drugs, methadone, chlordiazepoxide, metyrapone, pyrimethamine; xanthines (e.g., theophylline, aminophylline); levodopa, cyclosporine, isoniazid. Also, tell your doctor if you use any of the following drowsiness-causing drugs: sleep aids, sedatives, tranquilizers, anti-anxiety drugs like diazepam, narcotic pain relievers like codeine, psychiatric medicines, muscle relaxants, antihistamines like diphenhydramine. Check the labels carefully on all your medicines (e.g., cough- and-cold preparations) because they may contain drowsiness- causing ingredients. Ask your pharmacist about safe use of those products. CEREBYX may interfere with the effectiveness of birth control pills. Consult your doctor or pharmacist about other forms of birth control. CEREBYX may interfere with certain laboratory tests. Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.

CEREBYX OVERDOSE:
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, unconsciousness; unusually fast or slow heartbeat; muscle weakness or aches; severe dizziness, drowsiness, or stomach pain; fainting, or rapid breathing.

CEREBYX NOTES:
Laboratory and/or medical tests may be performed to monitor your progress.

MISSED CEREBYX DOSE:
If you miss a dose, contact your doctor or pharmacist promptly to establish a new dosing schedule.

CEREBYX STORAGE:
Store vials in the refrigerator between 36 and 46 degrees F (2 to 8 degrees C) away from light and moisture. After proper mixing with correct IV fluids (consult your pharmacist for details), CEREBYX is stable at room temperature for 8 hours and for 24 hours when refrigerated. Discard any unused liquid. Your condition can cause complications in a medical emergency. For information on enrollment call Medic Alert(TM) at 1-800-854- 1166. In Canada call 1-800-668-1507.